Selected research from leading health care experts whose findings have a direct bearing on public policies effecting medical progress. Research is chosen based on its quality and relevance by the Medical Progress Today editorial staff.

Selected Research

NSAIDs may be cardiotoxic: Hippisley-Cox and Carol Coupland, British Medical Journal
British Medical Journal, 6-11-05

As we noted above, researchers have uncovered some evidence that the entire class of painkillers known as non-steroidal anti-inflammatory drugs (NSAIDs) possesses some cardiovascular risk for certain groups of patients.

In a nested case-control analysis, Hippisley-Cox and Coupland…determined the comparative risk of myocardial infarction in patients taking cyclo-oxygenase-2 (COX 2) inhibitors and NSAIDs. All drugs in the study were associated with an increased risk of myocardial infarction, which was statistically significant for rofecoxib [Vioxx], diclofenac, and ibuprofen; no protective effect was seen for naproxen. The authors warn that this is an observational study and may be subject to residual confounding that cannot be fully corrected for.

Project FDA.
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