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Gene Map of the Extended Human MHC
MHC – the major histocompatibility complex – is the “most important region in the vertebrate genome in relation to infection, autoimmunity, and transplantation.” The MHC is also associated with “hundreds of diseases, including most, if not all, autoimmune diseases.” Several large studies of the MHC have recently been completed that “offer the opportunity to assimilate the latest data into an integrated map of the MHC”, a map that is presented in this article.
The extended MHC provides researchers with a valuable tool for charting the workings of the human immune system and translating that knowledge into new treatments for infectious diseases and autoimmune disorders.
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