|Selected research from leading health care experts whose findings have a direct bearing on public policies effecting medical progress. Research is chosen based on its quality and relevance by the Medical Progress Today editorial staff.||
Fluoxetine, Cognitive-Behavioral Therapy, and Their Combination for Adolescents With Depression
This study compared the relative effectiveness of fluoxetine (Prozac), cognitive-behavioral therapy, and placebo in adolescent patients with a diagnosis of major depressive disorder. The trial found that combination therapy (Prozac plus CBT) had the best response rate (71%) compared to Prozac alone (60%), CBT alone (43%) and placebo (35%). One interesting note given the recent hue and cry over a potential link between suicidal tendencies among adolescents and anti-depressant use: "Clinically significant suicidal thinking, which was present in 29% of the sample at baseline, improved significantly in all 4 treatment groups."
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